Genomic characterization of invasive meningococcal X isolates from Brazil, 19922022 / Caracterización genómica de aislamientos invasivos de meningococo X de Brasil, 19922022
Int. microbiol
; 26(3): 611-618, Ene-Agos, 2023. ilus, tab, graf
Article
in En
| IBECS
| ID: ibc-223986
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Introduction:
Invasive meningococcal disease (IMD) is a major health problem. Given the post-COVID-19 pandemic scenario with the loosening of the non-pharmacological measures to control the virus transmission and considering the observed global reduction of meningococcal vaccination coverage, an increase in IMD cases can be expected.Methodology:
Using whole-genome sequencing, we characterized six Neisseria meningitidis serogroup X (MenX) isolates recovered from IMD cases in Brazil in the last 30 years.Results:
The predominance (66.6%, 4/6) of ST2888 presenting fHbp 160, NHBA 129, NadA 21, and PorA 19,15 was found on isolates. Two novel STs, 15458 and 15477, were described.Conclusion:
This study describes the circulation of MenX lineage ST2888 in Brazil, previously reported only in Europe. Continuous universal surveillance is crucial to implement prompt public health measures aiming to prevent and control non-vaccine preventable serogroup X IMD cases.(AU)Key words
Full text:
1
Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Whole Genome Sequencing
/
Meningococcal Infections
/
Neisseria meningitidis
Limits:
Humans
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
Int. microbiol
Year:
2023
Document type:
Article